Endometriosis is one of the most common gynecological diseases that its main causes are not recognized yet. The disease affects 5-10% of women in reproductive age. The disease is usually accompanied with chronic pelvic pain, pain during menstruation or intercourse, abnormal menstruation and infertility. Endometriosis is a condition in which endometrial tissue grows outside the uterus, usually inside the abdominal cavity. The ectopic tissue like the normal tissue of the uterus has bleeding during the menstruation cycle. The recurrent bleeding in the abdominal cavity and pelvis makes scars and adhesions in these areas. It seems that the initiation of the disease is at the beginning of the second or third decade of life. Also, the disease can penetrate in the patient’s pelvis and affects the ovaries, intestine, bladder and other organs. The advanced form of the disease results in debilitating pain during menstruation and infertility which reduce the quality of life. About 30-50% of women are affected by different degrees of endometriosis. The definite diagnosis of the disease includes direct observation of the problem and biopsy through laparoscopic surgery. However, in cases like ovarian cysts, ultrasound diagnoses are of acceptable accuracy. Due to unknown nature of the disease and the need for advanced laparoscopic surgery, the diagnosis and treatment of the disease in all countries are carried out by specialized endometriosis teams and in well-equipped centers. For endometriosis treatment, in advanced and painful cases, surgery is the method of choice. In other cases, drug treatments have the first priority. Decisions about treatment should be borne by physicians familiar with this disease. Due to the progressive nature of the disease, early detection and treatment of the disease by methods like drug treatment or surgery and evaluation of the patient’s reproductive status for possible solutions may have effective roles in prevention of the disease’s side-effects like pain and infertility. Depending on the patient population and the need for early detection, the establishment of the clinic with experts from various fields in diagnosis and treatment of endometriosis, as one of the diseases with unknown causes, is one of the important requirements in hygiene and women health. Due to the unknown nature of the disease and the need for advanced laparoscopic surgery, diagnosis and treatment of endometriosis is present in all countries of the world by specialized teams of endometriosis and the centers are equipped. Laparoscopy Laparoscopy is a type of surgery carried out by making small holes in the abdomen. Through these holes, the tube with surgical instruments, cameras and proper lighting are sent inside the abdomen and pelvis and after the surgery, only a small scar will remain in the place. Other benefits of laparoscopic surgery compared with open surgery are fewer postoperative complications, faster return to daily life and less adhesion, infection and pain after surgery. Laparoscopic surgery is a suitable method with fewer complications for many women and its different types include ovarian cyst removal, hysterectomy, resection of myomas (fibroids), removal of ectopic pregnancy (EP) and endometriosis. By the help of proper light and magnification power of camera, endometriosis lesions in the pelvis and abdomen are observed accurately and are removed during the same surgery. Re-visits after surgery for evaluation of the treatment and follow-up visits for controlling the disease recurrence are necessary measures. Pelvic Pain, Endometriosis and Advanced Laparoscopy Clinic Endometriosis Clinic of Avicenna Fertility Center consisting of gynecologists and laparoscopy surgeons is the first subspecialized clinic in endometriosis. The endometriosis research group together with other treatment and research groups are determined to provide the best novel therapeutic approaches in targeting the disease. The main goal swivels round the timely diagnosis and treatment of patients with endometriosis and prevention of its multiple consequences. The certain sequence is the reduction of the number of infertilities induced by the disease. Through the measure, drug-resistant pain in some patients can be terminated and the improvement of patients’ quality of life as the ultimate goal of our center can be fulfilled. In this clinic, besides offering services based on updated science and appropriate treatment, the number of patients’ repeated visits would be reduced and the best services with lower costs will be provided for them.